Research on the protective effect of caffeic acid phenethyl ester on testicular damage caused by cisplatin

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Ceylan T., Kaymak E., CANTÜRK TAN F., YAKAN B.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.50, sa.8, ss.2032-2039, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 8
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-2002-58
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.2032-2039
  • Anahtar Kelimeler: Caffeic acid phenethyl ester, cisplatin, comet assay, rat, testes, INDUCED NEPHROTOXICITY, INJURY
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Background/aim: Cisplatin (CP), a chemotherapeutic drug, causes damage to spermatogenic serial cells, Sertoli cells, and Leydig cells in rat testicles. It was aimed to investigate the protective effect of caffeic acid phenethyl ester (CAPE), one of the active ingredients of propolis, in eliminating CP-induced testicular damage.