In vitro cytogenetic effects of Hypericum heterophyllum in human peripheral blood lymphocytes

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Ocal A., EROĞLU H. E.

BANGLADESH JOURNAL OF PHARMACOLOGY, cilt.7, sa.1, ss.36-41, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3329/bjp.v7i1.10119
  • Dergi Adı: BANGLADESH JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-41
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

In Hypericum species have been used in traditional medicine in Turkey for thousands of years. In order to determine the cytogenetic effects of Hypericum heterophyllum, human lymphocytes were incubated with the aqueous extracts. Mitotic index frequencies and replication index values were increased with increasing extract concentrations of H. heterophyllum. The results indicate the cytotoxic effects as well as proliferative effects and suggest that the extracts of the compounds exhibit cytotoxic properties as well as mitotic and proliferative properties.