Immunoreactive definition of TNF- alpha, HIF-1 alpha, Kir6.2, Kir3.1 and M2 muscarinic receptor for cardiac and pancreatic tissues in a mouse model for type 1 diabetes

Okan A., Doğanyiğit Z., Eroğlu E., Akyüz E., Demir N.

LIFE SCIENCES, cilt.284, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 284
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.lfs.2021.119886
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Type 1, Pancreatic, Kir6.2, Kir3.1, HIF-1 alpha, TNF-alpha, INDUCIBLE FACTOR-I, HYPOXIA, STREPTOZOTOCIN, EXPRESSION, CELLS, MELLITUS, COMPLICATIONS, MITOCHONDRIAL, ACTIVATION, CHANNELS
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Aim: Diabetes mellitus (DM) is characterized by insulin resistance or hyperglycemia caused by insufficient insulin secretion. Acetylcholine (ACh) can stimulate insulin release depending on glucose while hyperglycemia in DM pathology can cause cellular hypoxia. Adaptive responses to hypoxia in DM are associated with stimulation of hypoxia-inducible factor 1-alpha (HIF-1 alpha) signal due to hyperglycemia. Hypoxia affects potassium (K+) concentration by increasing excitability in K+ ion channels. In our study, we aimed to evaluate the immunoexpression of adaptive responses to hypoxia that develops with DM in pancreatic and cardiac tissues.