Serum sirtuin 1 levels in patients with polycystic ovary syndrome

Caglayan E. K., Engin-Ustun Y., GÖÇMEN A. Y., POLAT M. F., Aktulay A.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.35, sa.6, ss.608-611, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/01443615.2014.990428
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.608-611
  • Anahtar Kelimeler: PCOS, sirtuin 1, INSULIN-RESISTANCE, HISTONE DEACETYLASES, INFLAMMATION, GLUCOSE, HOMEOSTASIS, PHYSIOLOGY, DISORDERS, PROTECTS, DISEASE, ROLES
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Objective of the study is to determine the human nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 level in women with polycystic ovary syndrome (PCOS). This cross-sectional study included 24 patients aged 20-38 years, who were diagnosed to have PCOS (patient group). The control group included 16 age-and body mass index-matched healthy female volunteers. The patients and controls were compared in terms of pre-prandial blood glucose, the homoeostatic model assessment for insulin resistance (HOMA-IR) index, and cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C-reactive protein (CRP) and sirtuin 1 levels.