Comparison of Fine Needle Aspiration Biopsy and Specimen Histopathological Examinations of Salivary Gland Lesions

Can İ., Yazici H., Unlu I., Uzunkulaoglu H., Samim E.

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, vol.29, no.5, pp.1230-1234, 2009 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 5
  • Publication Date: 2009
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1230-1234
  • Yozgat Bozok University Affiliated: Yes


Objective: The goal was to compare fine-needle aspiration biopsy (FNAB) with subsequent specimen histopathological examinations of salivary gland lesions. Materials and Methods: In this retrospective study, 70 FNAB specimens of 83 patients were evaluated with subsequent histopathological examination of minor and major salivary gland lesions. There were 37 (44.6%) females and 46 (55.4%) males. The mean age was 43.22 +/- 18.34 (mean +/- standard deviation) ranging between 5-83 years. Biopsy sites included parotid glands in 44 cases, submandibular glands in 29 cases, buccal mucosa in 2 cases, hard palate in 6 cases, parapharyngeal region in I case and uvula in I case. Of the 83 patients, 70 (84.3%) underwent surgery and their specimens were evaluated. Histopathologically four aspirates were inadequate. Results: In evaluating histopathologically confirmed lesions, the absolute sensitivity in our series was 77.8% and the specificity was 93.4%. The positive predictive and the negative predictive values were 63.6% and 96.6% respectively. The accuracy rate was 91.4%. The agreement between cytological and subsequent histological diagnosis was 81.4% whereas 15.7% of the cases were discordant. Conclusion: FNAB is a commonly performed procedure. This technique is still valuable in the rapid diagnosis, staging and follow up of patients with salivary gland lesions. However, it requires a well-trained cytopathologist on salivary gland lesions and a good cooperation between the surgeon and the cytopathologist.