Involvement of Metabolites and Non-coding RNAs in Diseases

Coskun K. A., Kıyak B. Y., Cifci K., Kadioglu E., Yurekli N., Tutar Y.

Current Pharmaceutical Biotechnology, vol.24, no.7, pp.889-912, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 24 Issue: 7
  • Publication Date: 2023
  • Doi Number: 10.2174/1389201023666220921091240
  • Journal Name: Current Pharmaceutical Biotechnology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.889-912
  • Keywords: disease, Metabolism, metabolite analysis, metabolites, non-coding, RNAs
  • Yozgat Bozok University Affiliated: Yes

Abstract

Non-coding RNAs have a role in gene regulation and cellular metabolism control. Metabolism produces metabolites which are small molecules formed during the metabolic process. So far, a direct relationship between metabolites and genes is not fully established; however, pseudogenes and their progenitor genes regulate health and disease states. Other non-coding RNAs also contribute to this regulation at different cellular processes. Accumulation and depletion of metabolites accompany the dynamic equilibrium of health and disease state. In this study, metabolites, their roles in the cell, and the link between metabolites and non-coding RNAs are discussed.