Bee stings are commonly encountered worldwide, in the rural population in particular. We present the case of a young woman who was admitted with a complaint of severe persistent headache after a bee sting. Her routine laboratory, serologic, genetic, and coagulation tests were normal. Inflammatory, autoimmune, tumor, and hepatitis markers were negative. Magnetic resonance imaging showed a filling defect in the right sigmoid sinus and internal jugular vein. Lumbar puncture revealed an opening pressure of 250 mmH(2)O. Based on the diagnosis of internal jugular vein-sigmoid sinus thrombosis, the patient was treated with anticoagulation therapy resulting in a complete recovery within two weeks.