Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.13, sa.2, ss.83-95, 2005 (Scopus, TRDizin)
Application of extracorporeal circulation (ECC) in patients undergoing open heart surgery affects the hemostatic system detrimentally. The interaction of heparinised blood in the ECC with nonendothelial biomaterial leads to thrombin formation. Furthermore, induced hypothermia, drugs, and hemodilution activate the coagulation system and cause platelet dysfunction. Both Heparin, used for anti-coagulation during ECC, and Protamine, which is used for reversal, have many side effects. Alternative agents have been developed in cases where these drugs are contra-indicated. In this review, the physiology of coagulation and the effects of ECC on hemostasis are presented and precautions and clinical practice are overviewed.