Determination of the Physicochemical Properties of Piroxicam


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ÇELEBİER M., NENNİ M., KAPLAN O., AKGEYİK E. , KAYNAK M. S. , ŞAHİN S.

Turkish Journal of Pharmaceutical Sciences, vol.17, no.5, pp.535-541, 2020 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.82335
  • Title of Journal : Turkish Journal of Pharmaceutical Sciences
  • Page Numbers: pp.535-541
  • Keywords: Piroxicam, physicochemical properties, pKa, Log P, Log D, Log kw, WATER PARTITION-COEFFICIENTS, ACID DISSOCIATION-CONSTANTS, POTENTIOMETRIC DETERMINATION, PK(A) DETERMINATION, GRADIENT HPLC, PKA VALUES, RP-HPLC, LIPOPHILICITY, DISSOLUTION, VALIDATION

Abstract

Objectives: The aim of this study was to determine the acid dissociation constant (pKa) of piroxicam using high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectrophotometry, and to determine the partition coefficient (Log P), distribution coefficient (Log D), and "Log kw" values of piroxicam using HPLC.