Association Between Vitamin D Deficiency and the Development of Complex Regional Pain Syndrome: A Retrospective Case-Control Study
Acta Orthopaedica Belgica, cilt.91, ss.341-346, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 91
- Basım Tarihi: 2025
- Doi Numarası: 10.52628/91.3.13185
- Dergi Adı: Acta Orthopaedica Belgica
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL
- Sayfa Sayıları: ss.341-346
- Anahtar Kelimeler: Complex regional pain syndrome, physical medicine and rehabilitation unit, vitamin D deficiency, vitamin D insufficiency
- Yozgat Bozok Üniversitesi Adresli: Evet
Özet
Vitamin D deficiency has been suggested as a potential contributing factor in the development of Complex Regional Pain Syndrome (CRPS). This study aimed to investigate the association between serum vitamin D levels and CRPS using a retrospective case-control design. The study included 306 individuals divided into three groups: CRPS patients (n=102), fracture patients without CRPS (n=102), and healthy controls (n=102). Only patients whose vitamin D levels were measured during June, July, or August were included to minimize seasonal variation. Mean serum vitamin D levels were significantly lower in the CRPS group (10.2 ng/mL) compared to the fracture group (20.4 ng/mL) and control group (26.3 ng/mL) (p<0.001). The prevalence of vitamin D deficiency was highest in the CRPS group, followed by the fracture group, and lowest in the control group. Binary logistic regression analysis confirmed that vitamin D deficiency was independently associated with the presence of CRPS (OR: 14.57, 95% CI: 5.48–38.73, p<0.001), while age and sex were not significant predictors. No significant correlation was observed between serum vitamin D levels and other biochemical parameters. Vitamin D deficiency was more frequently observed in patients with CRPS than in fracture patients and healthy controls. These findings suggest an association between low vitamin D levels and the presence of CRPS. Further prospective studies are warranted.