Design, Synthesis, and Evaluation of Heat Shock Protein 90 Inhibitors in Human Breast Cancer and Its Metastasis


GÜMÜŞ M. , Ozgur A., Tutar L., DİŞLİ A., KOCA İ. , TUTAR Y.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY, vol.17, no.14, pp.1231-1245, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 14
  • Publication Date: 2016
  • Doi Number: 10.2174/1389201017666161031105815
  • Title of Journal : CURRENT PHARMACEUTICAL BIOTECHNOLOGY
  • Page Numbers: pp.1231-1245

Abstract

Background: Despite development of novel cancer drugs, invasive ductal breast carcinoma and its metastasis are still highly morbid. Therefore, new therapeutic approaches are being developed and Hsp90 is an important target for drug design. For this purpose, a series of benzodiazepine derivatives were designed and synthesized as novel Hsp90 inhibitor.