Akademik Veri Yönetim Sistemi
Journal of Clinical and Analytical Medicine, cilt.4, sa.5, ss.372-376, 2013 (Scopus, TRDizin)
Aim: To evaluate the effects of proton-pump inhibitor (PPI) use on distrubtion of intestinal flora by measuring serum Clostridium Difficile antigen levels before and at the end of a three-months treatment in patients with Laryngopharyngeal reflux (LFR) treatment. Material and Method: The study covers 32 patients with LFR, out of which 24 were female (75%) and 8 were male (25%). The mean age of the patients was 34.13 ± 11.59. All patients included in the study were administered Lansoprazole 30 mg tablets perorally before meals and twice a day for treatment. Reflux Symptom Index (RSI), Reflux Finding Score (RFS), white blood cell count, CRP and serum Clostridium Difficile toxin A, B measurement results were comparatively evaluated through the blood serum samples drawn from the patients before and at the end of the three-months treatment. Results: While the mean values of pre-treatment RSI and RFI were 20.81±4.05 and 13.31±3.30 respectively, the mean values were measured to be 3.41±2.37 and 1.50±1.88 respectively following the three-months treatment (p< 0.05). The pre-treatment mean value of serum Clostridium Difficile Ag was 140.56±11.74, while it was seen that the same value became 114.94±10.70 after the three-months treatment (p< 0.05). There was, however, no statistically significant change in the other parameters. Discussion: According to the results obtained, it was seen that the treatment with PPI was not cause to increase Clostridium difficile toxin A, B serum antigen levels. So these drugs could be used in long time therapies confidently.