Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats

APAYDIN F. G., ASLANTÜRK A., UZUNHİSARCIKLI M., BAŞ H., KALENDER S., KALENDER Y.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, vol.26, no.12, pp.12302-12310, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 12
  • Publication Date: 2019
  • Doi Number: 10.1007/s11356-019-04578-4
  • Journal Name: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.12302-12310
  • Keywords: Bisphenol A, Curcumin, Taurine, Electron microscopy, Light microscopy, Heart, DIABETES-MELLITUS, OXIDATIVE STRESS, RUMEX-PATIENTIA, EXPOSURE, ACARBOSE
  • Yozgat Bozok University Affiliated: Yes

Abstract

Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and also histopathological and cytopathological changes of heart were studied. No significant changes in all studied parameters were seen between control, olive oil, curcumin, and taurine-treated groups. However, there were significant differences in levels of malondialdehyde and activities of antioxidant enzymes in BPA-exposed rats and some histo/cytopathological changes determined. In curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we measured the preventive effects on some parameters but not exactly. As a result, curcumin and taurine significantly minimized BPA-induced cardiotoxicity in rats.