The effect of a natural molecule in ovary ischemia reperfusion damage: does lycopene protect ovary?


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AYDOĞAN KIRMIZI D., BAŞER E., OKAN OFLAMAZ A., Kara M., YALVAÇ E. S., DOĞANYİĞİT Z.

EXPERIMENTAL ANIMALS, vol.70, no.1, pp.37-44, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1538/expanim.20-0080
  • Journal Name: EXPERIMENTAL ANIMALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.37-44
  • Keywords: ischemia-reperfusion, lycopene, ovary, rat, ISCHEMIA/REPERFUSION-INJURY, ADNEXAL TORSION, DETORSION, INFLAMMATION, MACROPHAGES, RESERVE, MODEL, RATS
  • Yozgat Bozok University Affiliated: Yes

Abstract

Ovarian ischemia is a gynecological emergency case that occurs as a result of ovarian torsion. Oxidative stress plays a central role in the development of ischemia/reperfusion (IR) injuries. Lycopene (LYC) is a lipophilic, natural carotenoid well known for its antioxidant properties. This study provides information on the potential applications of lycopene. The Wistar Albino rats were distributed into six groups: Sham group (only a laparotomy was performed), Control group [laparotomy and intraperitoneal dissolvent (olive oil)], IR group, IR+olive oil group, IR+LYC 2.5 mg/kg/dose, intraperitoneal group, IR+LYC 5 mg/kg/dose intraperitoneal group. Evaluated in terms of histopathological changes, tissue malondialdehyde levels (MDA), ovarian expressions of phosphorylated nuclear factor-kappa B (p-NF-kappa B) and the TUNEL method was utilized to show apoptosis of ovarian tissue. There was a significant decrease in MDA, p-NF-kappa B values and the proportion of apoptotic cells assessed by TUNEL compared to the group that did not receive intraperitoneal LYC in rat injury with IR damage (P<0.05). In histopathological damage scoring, it was observed that the cell damage was significantly reduced in LYC-administered groups. LYC showed significant ameliorative effects on ovary injury caused by IR through acting as an antioxidant, antiinflammatory, and antiapoptotic agent.