Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes

Ahmadian E., Eftekhari A., Kavetskyy T., Khosroushahi A. Y. , TÜRKSOY V. A. , Khalilov R.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, vol.167, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 167
  • Publication Date: 2020
  • Doi Number: 10.1016/j.pestbp.2020.104586
  • Title of Journal : PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
  • Keywords: Herbicide, Environmental pollutant, Quercetin, Nanostructured lipid carriers, Blood lymphocytes, PERIPHERAL-BLOOD LYMPHOCYTES, N-ACETYLCYSTEINE, CELL-DEATH, NANOPARTICLES, DELIVERY, CANCER, DAMAGE, INTOXICATION, NANOCRYSTALS, MECHANISMS

Abstract

Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared using Ficoll polysaccharide and subsequently by gradient centrifugation. The QNLC was prepared using an ultrasonication method, which was characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM).