Atraumatic osteonecrosis after estrogen replacement therapy associated with low protein s level in a patient with turner syndrome

Üreten K., ÖZTÜRK M. A., Bostanci A., Çeneli Ö., Özbek M., HAZNEDAROĞLU İ. C.

Clinical and Applied Thrombosis/Hemostasis, cilt.16, sa.5, ss.599-601, 2010 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/1076029609339746
  • Dergi Adı: Clinical and Applied Thrombosis/Hemostasis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.599-601
  • Anahtar Kelimeler: Estrogen, Osteonecrosis, Protein S deficiency
  • Yozgat Bozok Üniversitesi Adresli: Hayır

Özet

Atraumatic osteonecrosis has been associated with a variety of clinical conditions including corticosteroid usage, alcoholism, infections, hyperbaric events, storage disorders, marrow-infiltrating diseases, coagulation defects, and some autoimmune diseases. Osteonecrosis due to thrombophilia is an extremely rare condition with only few cases reported previously in the literature. Hormone-replacement therapies cause increased risk of venous thrombosis, probably by causing a synergistic effect with inherited clotting defects. In this article, we report a young female with Turner syndrome, who developed avascular necrosis of the femoral head during treatment with oral estrogen, which was associated with low protein S levels.