Cabazitaxel causes a dose-dependent central nervous system toxicity in rats


KARAVELİOĞLU E., Gonul Y., AKŞİT H., BOYACI M. G. , KARADEMİR M., ŞİMŞEK N., ...More

JOURNAL OF THE NEUROLOGICAL SCIENCES, vol.360, pp.66-71, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 360
  • Publication Date: 2016
  • Doi Number: 10.1016/j.jns.2015.11.033
  • Title of Journal : JOURNAL OF THE NEUROLOGICAL SCIENCES
  • Page Numbers: pp.66-71

Abstract

Background: Chemotherapeutic agents may lead to serious neurological side effects, which in turn can deteriorate the quality of life and cause dose limiting. Direct toxic effect or metabolic derangement of chemotherapeutic agents may cause these complications. Cabazitaxel is a next generation semi-synthetic taxane derivative, which is effective in both preclinical models of human tumors sensitive or resistant to chemotherapy and in patients with progressive prostate cancer despite docetaxel treatment.