Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors


GERGERLİOĞLU H. S., Oz M., Demir E. A., NURULLAHOĞLU ATALIK K. E., YERLİKAYA F. H.

LIFE SCIENCES, cilt.148, ss.279-285, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 148
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.lfs.2016.02.011
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.279-285
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Aims: Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and memory in theHFD-induced cognitive deficits, but the exact mechanismis still not clearly understood. Therefore, the present study aimed to clarify the effects of the EE on spatial memory in WD-fed rats, and to analyze the potential role of corticosteroid receptors in the EE conditioning.