Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors

GERGERLİOĞLU H. S., Oz M., Demir E. A., NURULLAHOĞLU ATALIK K. E., YERLİKAYA F. H.

LIFE SCIENCES, vol.148, pp.279-285, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 148
  • Publication Date: 2016
  • Doi Number: 10.1016/j.lfs.2016.02.011
  • Journal Name: LIFE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.279-285
  • Yozgat Bozok University Affiliated: Yes

Abstract

Aims: Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and memory in theHFD-induced cognitive deficits, but the exact mechanismis still not clearly understood. Therefore, the present study aimed to clarify the effects of the EE on spatial memory in WD-fed rats, and to analyze the potential role of corticosteroid receptors in the EE conditioning.