Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors
LIFE SCIENCES, vol.148, pp.279-285, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 148
- Publication Date: 2016
- Doi Number: 10.1016/j.lfs.2016.02.011
- Journal Name: LIFE SCIENCES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.279-285
- Yozgat Bozok University Affiliated: Yes
Abstract
Aims: Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and memory in theHFD-induced cognitive deficits, but the exact mechanismis still not clearly understood. Therefore, the present study aimed to clarify the effects of the EE on spatial memory in WD-fed rats, and to analyze the potential role of corticosteroid receptors in the EE conditioning.