Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?
ARCHIVES OF MEDICAL SCIENCE, vol.18, no.5, pp.1364-1371, 2022 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 18 Issue: 5
- Publication Date: 2022
- Doi Number: 10.5114/aoms.2019.90414
- Journal Name: ARCHIVES OF MEDICAL SCIENCE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
- Page Numbers: pp.1364-1371
- Keywords: cisplatin, ovary, oxidative stress, pycnogenol, rat, uterus, PINE BARK EXTRACT, ANTIOXIDANT ACTIVITY, OXIDATIVE STRESS, RAT MODEL, INFLAMMATION, THIAMINE, ASSAY
- Open Archive Collection: AVESIS Open Access Collection
- Yozgat Bozok University Affiliated: Yes
Abstract
Introduction: Cisplatin is an antineoplastic agent, which is thought to act on tissues with increased levels of reactive oxygen species and decreased levels of antioxidants. Pycnogenol is a potent antioxidant that is used in medical conditions caused by oxidative stress. The aim of our study is to demonstrate the effects of pycnogenol on cisplatin-induced uterine and ovarian damage in rats.