Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?

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Turkler C., KİREMİTLİ T., ONAT T., Yildirim E., YAZICI G. N., MAMMADOV R., ...Daha Fazla

ARCHIVES OF MEDICAL SCIENCE, cilt.18, sa.5, ss.1364-1371, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5114/aoms.2019.90414
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.1364-1371
  • Anahtar Kelimeler: cisplatin, ovary, oxidative stress, pycnogenol, rat, uterus, PINE BARK EXTRACT, ANTIOXIDANT ACTIVITY, OXIDATIVE STRESS, RAT MODEL, INFLAMMATION, THIAMINE, ASSAY
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Introduction: Cisplatin is an antineoplastic agent, which is thought to act on tissues with increased levels of reactive oxygen species and decreased levels of antioxidants. Pycnogenol is a potent antioxidant that is used in medical conditions caused by oxidative stress. The aim of our study is to demonstrate the effects of pycnogenol on cisplatin-induced uterine and ovarian damage in rats.