Can pycnogenol prevent cisplatin-induced damage in uterus and ovaries?

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Turkler C., KİREMİTLİ T., ONAT T., Yildirim E., YAZICI G. N., MAMMADOV R., ...More

ARCHIVES OF MEDICAL SCIENCE, vol.18, no.5, pp.1364-1371, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.5114/aoms.2019.90414
  • Journal Name: ARCHIVES OF MEDICAL SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1364-1371
  • Keywords: cisplatin, ovary, oxidative stress, pycnogenol, rat, uterus, PINE BARK EXTRACT, ANTIOXIDANT ACTIVITY, OXIDATIVE STRESS, RAT MODEL, INFLAMMATION, THIAMINE, ASSAY
  • Yozgat Bozok University Affiliated: Yes

Abstract

Introduction: Cisplatin is an antineoplastic agent, which is thought to act on tissues with increased levels of reactive oxygen species and decreased levels of antioxidants. Pycnogenol is a potent antioxidant that is used in medical conditions caused by oxidative stress. The aim of our study is to demonstrate the effects of pycnogenol on cisplatin-induced uterine and ovarian damage in rats.