Brucellosis is a common infectious disease that is common in Turkey, as in other Mediterranean countries. It is a zoonosis that humans contract by either direct contact with infected animals or ingestion of raw meat or unpasteurized milk from such animals. It causes various symptoms, such as muscle and joint pains and headache. Neurobrucellosis may cause paresis, neuritis, meningoencephalitis, myelitis, psychosis, and rarely Guillain-Barre syndrome. Diagnosis of brucellosis is difficult owing to the nonspecific symptoms of the disease. A definite diagnosis was made by the isolation of the microorganism from the blood, cerebrospinal fluid, bone marrow, and other tissues. We discuss two cases with paraparesis due to brucellosis.