Effects of short- and long-term use of propolis extracts on liver and kidney in rats

SİLİCİ S., Demiray S., OKAN OFLAMAZ A., Ertuğrul S., Alizada S., DOĞANYİĞİT Z.

Food Science and Nutrition, cilt.12, sa.8, ss.5538-5547, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 8
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1002/fsn3.4199
  • Dergi Adı: Food Science and Nutrition
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, Food Science & Technology Abstracts, Greenfile, Directory of Open Access Journals
  • Sayfa Sayıları: ss.5538-5547
  • Anahtar Kelimeler: ethanol, hepatic, olive oil, propolis, renal
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Propolis is widely used as a supplementary food product for its health benefits. The aim of this study was to determine the effects of commercial propolis extracts on the liver and kidney. Propolis extracts (250 mg/kgbw/day) were administered orally to adult male Wistar albino rats in solvents of ethanol, propylene glycol, water, and olive oil. Liver enzyme levels were determined biochemically in blood samples, and histopathological examinations were performed on the liver. Damage rate in both kidney tissue in the propolis-ethanol extract group increased significantly compared with the other groups after 30 and 90 days of application (p <.05). According to the results, ethanol, used as a common solvent in propolis products, may adversely affect the liver in long-term use. The data indicate that propolis-olive oil extract may be an essential alternative due to its effective and reliable properties.