The genotoxic effect of nicotine on chromosomes of human fetal cells: The first report described as an important study

DEMİRHAN O., Demir C., Tunc E., İNANDIKLIOĞLU N., Sutcu E., Sadikoglu N., ...More

INHALATION TOXICOLOGY, vol.23, no.13, pp.829-834, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 13
  • Publication Date: 2011
  • Doi Number: 10.3109/08958378.2011.617398
  • Journal Name: INHALATION TOXICOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.829-834
  • Keywords: Nicotine, genotoxicity, human fetal cells, chromosome aberrations, MATERNAL CIGARETTE-SMOKING, LIFE-STYLE FACTORS, IN-VITRO, COTININE CONCENTRATIONS, MEIOTIC MATURATION, HUMAN SPERMATOZOA, HUMAN OOCYTES, DNA-DAMAGE, ANEUPLOIDY, SMOKERS
  • Yozgat Bozok University Affiliated: No

Abstract

Context: Recent studies have suggested a direct contribution of nicotine - the addictive component of tobacco and tobacco smoke - to human carcinogenesis, and it remains the most common harmful substance to which pregnant women are exposed. Also, it has deleterious effects on the fetus. The sperm of smoking fathers and newborns of smoking mothers have elevated frequencies of chromosome translocations and DNA strand breaks.