Two efficient methods for the total synthesis of the natural diarylheptanoid 7-(4-hydroxyphenyl)-1-phenylheptan-3-one

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Gürel E., Kaya T., Çelebioğlu N., Seçinti-Klopf H., SEÇEN H.

Organic Communications, cilt.17, sa.2, ss.115-122, 2024 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.25135/acg.oc.169.24.05.3254
  • Dergi Adı: Organic Communications
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.115-122
  • Anahtar Kelimeler: 7-(4-hydroxyphenyl)-1-phenylheptan-3-one, Alpinia officenarum, Linear diarylheptanoid, natural product, total synthesis
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Diarylheptanoids are compounds with an ArC7Ar structure, where two aromatic rings are connected by a seven-carbon chain. To date, over 500 structurally diverse diarylheptanoids have been isolated from nature. These compounds are generally minor secondary metabolites found in plants. Natural diarylheptanoids possess a wide range of biological activities, making their short and efficient total synthesis important for enabling further research on these substances. In this study, two efficient synthesis methods developed for the compound 7-(4-hydroxyphenyl)-1- phenylheptan-3-one, which is isolated as a minor component from Alpinia officinarum, are presented.