Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.19, sa.3, ss.170-173, 1991 (Scopus)
The purpose of this study is to compare the hemodynamic effects of 'Propofol' between the patients presenting for valve replacement (Group 1) and coronary artery surgery (Group II). The night and two hours before operation, premedication was done by using diazepam 10 mg orally. In these patients, anaestheia was induced with diazepam 0.15-0.2 mg/kg, propofol 1-2 mg/kg and vecuronium 0.1 mg/kg and intravenous propofol infusion, 5 mg/kg/hr, was started. After intubation % 50-50 O2-N2O mixture was added to propofol. After sternotomy, IV propofol infusion, 2.5 mg/kg/hr was continued during anaesthesia. After induction, SAP, DAP and MAP were decreased markedly in group II; after intubation the increase in SAP, DAP and MAP was higher in group I than group II, and the increase in IIR and SAP was higher in group I than group II but the decrease in DAP and MAP was higher in group II. As a result of this study, we concluded that the use of propofol infusion (with N2O addition) as a sole anaesthetic agent in open heart surgery may produce a good hemodynamic stability in patients with coronary artery disease who has good left ventricular function and valvular heart disease. During the propofol infusion used in patients with coronary artery disease, the anaesthesiologist has to be very careful about the reactions to surgical stimulus.