Mycobacterium lentiflavum is a relatively rare cause of infection. Cases of human diseases have been reported. Most of the patients are immunocompromised. Here, we present an immunocompetent patient with pulmonary disease. The patient has come with chronic cough and hemoptysis. On computed thoracic tomography, there were bilateral cavitating centriacinar nodules, bronchiectasis, and tree-in-bud pattern. Microbiological analysis of bronchoalveolar lavage fluid grew M. lentiflavum. Her symptoms are relieved with ethambutol, clarithromycin, and rifabutin. Nontuberculous mycobacteria are an emerging problem worldwide. Necessity of treatment depends on the patient.