Akademik Veri Yönetim Sistemi
Indian Journal of Forensic Medicine and Pathology, cilt.13, sa.1, ss.145-155, 2020 (Scopus)
Vitamin D deficiency is common in the World and Turkey due to changing lifestyles.
The association with autoimmune diseases such as obesity, metabolic syndrome, diabetes,
cardiovascular diseases and important diseases such as cancer has made it important to prevent
vitamin D deficiency. Fetuin-A is a glycoprotein produced in the liver and it is effective in the
inhibition of bone mineralization, insulin resistance, obesity and calcification in smooth muscle.
In the study conducted, it was aimed to investigate the relationship between the two substances
in growth retardation, considering that Vitamin D and Fetuin-A are acting through similar
mechanisms. The study was conducted with 50 healthy children with growth retardation. In
short patients and underweight patients, vitamin D levels were found to be lower than control
group (respectively p = 0,011 p = 0,036). As vitamin D value increased one unit, it was found
that the risk of growth retardation decreased by 1,071 times (p = 0,21). Fetuin-A levels were
higher in those with growth retardation (p = 0,035). In the preschool group, fetuin-A was higher
than middle childhood (p < 0,001). In short patients, fetuin-A levels were higher than control
groups (p = 0,043). There was a poor correlation between vitamin D and fetuin-A levels in those
with growth retardation (rho: 0,366 p = 0,009). Fetuin-A levels were higher in short children
and there was a positive relationship between vitamin D and fetuin-A levels in those with
growth retardation. Vitamin D levels were lower in those with growth retardation.