This study is an analysis of manufacturing industry clustering in Yozgat in 5-year periods during the years of 2006 to 2016 using the location quotient method. This method is a readily accessible means of performing a spatial evaluation of statistical data. This research investigated which cities in Yozgat have manufacturing industry clusters, which cities' manufacturing industries merit further investment, compatibility with 2013 regional planning proposals, and tendencies in manufacturing industry clustering over the years. According to the number of employees in Yozgat in 2006, there were only manufacturing industry clusters in the districts of Yerkoy and Sorgun. There were manufacturing industry clusters in 6 more regions in 2011. By 2016, the districts of Yerkoy, Sorgun, Bogazliyan, and Cayiralan had manufacturing industry clusters. Another important result is that the proximity of Bogazliyan and Cayiralan to the city of Kayseri provides them with widespread trickle-down effects. This research was performed using the fourth level of the equivalent to the subregions of nomenclature of units for territorial statistics (NUTS-4), and is one of the first such studies of Yozgat.