Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

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GÜLER M. C., TANYELİ A., ERASLAN E., Ekinci Akdemir F. N., Nacar T., TOPDAĞI Ö.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.26, no.3, pp.365-370, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 2020
  • Doi Number: 10.9775/kvfd.2019.23250
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.365-370
  • Yozgat Bozok University Affiliated: Yes


The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion.