Matrix changes due to the toxic effects of metronidazole in intestinal tissue of fish (Onchorhynchus mykiss)

Gurcu B., Koca Y. B., Ozkut M. M., Tuglu M. I.

CHEMOSPHERE, vol.144, pp.1605-1610, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144
  • Publication Date: 2016
  • Doi Number: 10.1016/j.chemosphere.2015.10.043
  • Journal Name: CHEMOSPHERE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1605-1610
  • Keywords: Metronidazole, Toxicity, Connective tissue, Extracellular matrix, Intestine, Onchorhynchus mykiss, BASEMENT-MEMBRANE, RAINBOW-TROUT, DEGRADATION, TARGETS
  • Yozgat Bozok University Affiliated: No


Metranidazole (MTZ) is an antibiotic used for parasitic infections in a number of species. Accumulation of this drug in the environment and its interaction with fish of economic value makes this drug particularly important. In the present study, we examined the histopathological effects of MTZ on the intestinal tissue of Oncorhynchus mykiss.