Matrix changes due to the toxic effects of metronidazole in intestinal tissue of fish (Onchorhynchus mykiss)

Gurcu B., Koca Y. B. , Ozkut M. M. , Tuglu M. I.

CHEMOSPHERE, vol.144, pp.1605-1610, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 144
  • Publication Date: 2016
  • Doi Number: 10.1016/j.chemosphere.2015.10.043
  • Title of Journal : CHEMOSPHERE
  • Page Numbers: pp.1605-1610
  • Keywords: Metronidazole, Toxicity, Connective tissue, Extracellular matrix, Intestine, Onchorhynchus mykiss, BASEMENT-MEMBRANE, RAINBOW-TROUT, DEGRADATION, TARGETS


Metranidazole (MTZ) is an antibiotic used for parasitic infections in a number of species. Accumulation of this drug in the environment and its interaction with fish of economic value makes this drug particularly important. In the present study, we examined the histopathological effects of MTZ on the intestinal tissue of Oncorhynchus mykiss.