Objectives: Asbestos-related lung diseases are a major health concern worldwide causing lung, pleural, and respiratory tract cancers, mesothelioma and hyalinized calcified pleural plaques as well as pulmonary fibrosis. We aimed to analyze some biochemical parameters in asbestosis and mesothelioma. Materials and methods: The study was performed at Bozok University and Selcuk University, Medicine Faculty. Group 1 (healthy control group, n = 27) consisted of healthy individuals without any chronic disease and regular use of drugs. Group 2 (patient group, n = 34) was comprised of patients diagnosed with mesothelioma and/ or pleural plaques and asbestosis after evaluation of clinical, pathological, and radiological analysis. Aluminum (Al), chromium (Cr), cobalt (Co), nickel (Ni), zinc (Zn), arsenic (As), cadmium (Cd), lead (Pb) as well as vitamin D and 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations were determined in blood samples. Results: 8-OHdG and Al, Co, Cu, As, Cd, and Pb levels in the patient group were statistically higher than in the healthy control group (p <= 0.05). The differences between the groups' Cr, Ni, Zn levels were not important. Vitamin D levels were correlated with Al and 8-OHdG levels. Vitamin D levels were higher in the healthy control group (p = 0.000). Conclusion: DNA damage occurred in asbestosis and mesothelioma patients. Determination of the changes in blood levels of trace elements, especially Al, Co, As, Cd, Pb, and vitamin D, in those patients will create basic data for further studies which might lead to therapeutic applications.