Alteration of thiol-disulfide homeostasis in workers occupationally exposed to arsenic


Buyuksekerci M., BAL C., Serkant U., Gunduzoz M., Alisik M., TUTKUN E. , ...More

ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH, vol.73, no.2, pp.90-95, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1080/19338244.2017.1287047
  • Title of Journal : ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
  • Page Numbers: pp.90-95

Abstract

This study evaluates the redox state in occupationally arsenic-exposed workers (n = 71) by assessing the dynamic serum thiol-disulfide homeostasis. We determined the serum thiol-disulfide homeostasis parameters of exposed workers and controls (n = 43) using a novel automated colorimetric assay. Median urinary As and 8-isoprostane levels of exposed group were significantly higher than control group (16.40 mg/L vs 2mg/L, p < .001 and 2.28 ng/ml vs 0.54 ng/ml, p < .001, respectively). Disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio were significantly higher in exposed group. The mean ceruloplasmine and myeloperoxidase activities of As-exposed group were significantly higher than control group (117.15 U/L vs 87.02 U/L, p = .035 and 148.53 U/L vs 97.75 U/L, p = .000, respectively). The median catalase activity did not differ in the two groups. Our findings revealed that As disrupts the thiol-disulfide homeostasis in favor of disulfide.