This paper presents a parametric study of the collapse performance of two-story residential buildings equipped with a simple spherical concave deformable rolling isolation system cast in high strength concrete. The collapse performance follows the procedures of FEMA P695 with direct evaluation of the spectral shape effects and accounts for uncertainties. The isolation system consists of isolators with fixed dimensional parameters that include a displacement restraint system and have a displacement capacity of 650 mm. The designs considered in the study have properties that are representative of highly ductile reinforced concrete two-story residential buildings consisting of moment frames and/or shear walls designed in Turkey for a lateral force under elastic conditions corresponding to a spectral acceleration of 1 g. This is representative of areas of the highest seismic hazard in Turkey except for areas controlled by near-fault conditions. The simplicity in the design of the structural system and of the isolation system intend to facilitate application of the system without sophisticated analysis. The seismic collapse performance evaluation demonstrates that residential buildings designed by this procedures and using this isolation system have acceptable collapse performance as stipulated in the ASCE/SEI 7-16 standard.