In this paper, the real-time supervisory control of an experimental manufacturing system is reported based on a recently proposed hybrid (mixed PN/automaton) approach. Assuming that an uncontrolled bounded Petri net (PN) model of a (plant) discrete event system (DES) and a set of forbidden state specifications are given, the proposed approach computes a maximally permissive and nonblocking closed-loop hybrid model. The method is straightforward logically, graphically and technologically. This paper particularly shows the applicability of a hybrid (mixed PN/automaton) approach to low-level real-time DES control. To do this, programmable logic controller (PLC) based real-time control of an experimental manufacturing system is considered. (C) 2009 Elsevier Ltd. All rights reserved.