The protective effects of hesperidin pretreatment on kidney and remote organs against renal ischemia-reperfusion injury
European Review for Medical and Pharmacological Sciences, vol.27, no.7, pp.2808-2814, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27 Issue: 7
- Publication Date: 2023
- Doi Number: 10.26355/eurrev_202304_31911
- Journal Name: European Review for Medical and Pharmacological Sciences
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Page Numbers: pp.2808-2814
- Keywords: Hesperidin, Renal ischemia-reperfusion, Injury, Remote organ, Lung
- Yozgat Bozok University Affiliated: Yes
Abstract
OBJECTIVE: As an antioxidant and anti-inflammatory agent, Hesperidin was investigated to prove whether it prevents damage to the kidney and lung tissues of rats undergoing renal ischemia-reperfusion injury. MATERIALS AND METHODS: Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal ischemia reperfusion), Groups 3 and 4 as pretreatment groups (50 HES, 100 HES). RESULTS: According to our results, Hesperidin pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg. CONCLUSIONS: The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reperfusion injury.