One-pot and multi-step syntheses of new 2-(4,5-dihydro-1H-pyrazol-1-yl) thiazole derivatives


GÜMÜŞ M. , DİŞLİ A., YAKAN M. , Yigitcan S., KOCA İ.

ORGANIC COMMUNICATIONS, vol.11, no.2, pp.98-110, 2018 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.25135/acg.oc.40.18.03.071
  • Title of Journal : ORGANIC COMMUNICATIONS
  • Page Numbers: pp.98-110

Abstract

beta-Ketoester and ethanone derivatives, potentially functional molecules, containing the pyrazole/thiazole scaffolds were synthesized. The structures of the synthesized novel compounds were confirmed by FTIR, H-1 NMR and C-13 NMR spectroscopy and elemental analysis. The NMR spectra of the synthesized compounds are analyzed. Furthermore, ABX systems in pyrazole ring were studied in detail and the coupling constants of the diastereotopic protons.