Multifunctional "Janus-Type" Bilayer Films Combine Broad-Range Tissue Adhesion with Guided Drug Release

Kimna C., Bauer M. G., Lutz T. M., Mansi S., Akyuz E., DOĞANYİĞİT Z., ...Daha Fazla

ADVANCED FUNCTIONAL MATERIALS, cilt.32, sa.30, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 30
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/adfm.202105721
  • Dergi Adı: ADVANCED FUNCTIONAL MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: asymmetric design, bioadhesive, hyaluronic acid, mucin, wound management, HYALURONIC-ACID, POLY(VINYL ALCOHOL), IN-VIVO, HYDROGEL, BIOMATERIALS, POLYMERS
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Tissue healing is a challenging process that requires the successful and simultaneous management of conflicting priorities. While promoting wound closure, a battle must be won against different external factors that may adversely affect the healing process. Here this problem is approached by creating asymmetrically designed double-layer Janus-type bilayer films where distinct functions are implemented into the two sides of the film. Once deployed, those Janus-type films exhibit strong adhesion to a wide variety of wet tissues and canalize the release of integrated therapeutics toward the tissue side. At the same time, the outer surface of the films acts as a shield against tribological stress, pathogens, and cellular immune recognition. Moreover, when compared to untreated wounds, Janus-treated skin lesions show accelerated wound closure as well as fast formation of new, intact tissue. Having performed their tasks, Janus-type films degrade without leaving any traces on the tissues, which makes it possible to apply them to sensitive body surfaces. Thus, it is expected that the Janus-type bilayer films designed here can be used in a variety of medical applications where conflicting demands must be met at the same time.