Measurement of mucociliary clearance in the patients with multiple sclerosis

ŞAHİN E., HAMAMCI M., Kantekin Y.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol.277, no.2, pp.469-473, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 277 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.1007/s00405-019-05717-w
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.469-473
  • Yozgat Bozok University Affiliated: Yes


Objectives The aim of the present study was to measure nasal mucociliary clearance (NMC) time in the patients with MS and to compare the findings with healthy population. Methods Totally 97 individuals including 47 patients with relapsing-remitting multiple sclerosis and 50 healthy volunteers were enrolled into the study. Saccharin clearance test was performed on both groups and NMC time was measured. Data analysis was performed by SPSS version 24.0 statistics program (SPSS Inc., Chicago, Illinois, USA). Statistical tests were interpreted at p < 0.05 significance level. Results The NMC time averages in MS patients and healthy control group were 12.43 +/- 4.05 min and 8.14 +/- 2.87 min, respectively; the difference between the groups was significant (p < 0.001). There was a statistically strong association between NMC time values and Expanded Disability Status Scale (EDSS) values in MS patients (r = 0.817, p < 0.001). Conclusion We found nasal mucociliary transport time longer in MS patients than healthy population in the present study. To the best of our knowledge, there is not any study conducted about this topic in the literature. We believe that our findings would shed a light on further studies.