The Effects of Cadmium on Enzymatic Antioxidant System and Lipid Peroxidation of Human Erythrocytes in vitro and the Protective Role of Plasma Level of Vitamins C and E

Tezcan O., PANDIR D., BAŞ H.

POLISH JOURNAL OF ENVIRONMENTAL STUDIES, vol.21, no.6, pp.1849-1854, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 2012
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1849-1854
  • Keywords: antioxidant enzymes, cadmium, vitamins C and E, erythrocytes, in vitro, INDUCED OXIDATIVE STRESS, DNA-DAMAGE, INDUCED APOPTOSIS, DEFENSE SYSTEM, ASCORBIC-ACID, INDUCTION, SELENIUM, BLOOD, METAL, RATS
  • Yozgat Bozok University Affiliated: Yes


In our study, the effect of simultaneous pretreatment with plasma levels of vitamins C and E on the toxicity of CdCl2 in human erythrocytes was evaluated. We aimed to examine how several different doses of CdCl2 or CdCl2, in combination with vitamins, affects lipid peroxidation and the antioxidant defense system in vitro. Levels of malondialdehyde and the activities of antioxidant enzymes changed in CdCl2-treated groups in different concentrations. Vitamin-pretreated erythrocytes showed significant protection aganist the cytotoxic effects induced by low and moderate CdCl2 concentrations on the studied parameters.