Aim: The aim of the study was to evaluate angiogenesis-related parameters including vascular endothelial growth factor (VEGF), p300 expression, and microvessel density (MVD) in plasma cell myeloma (PCM). Material and Method: p300, VEGF, and Factor related antigen (for measurement of MVD) were applied to the para n-embedded bone marrow sections of 45 patients with PCM, immunohistochemically. Histomorphologic factors, clinical and laboratory findings, and overall survival (OS) were correlated with p300 and VEGF expression, and MVD. Results: VEGF overexpression (>= 50) was significantly associated with diffuse infiltration pattern and high percentage of plasma cell infiltration (p=0.014, p=0.002, respectively). Higher MVD was directly correlated with diffuse infiltration pattern and increased CRP levels (p=0.026, p=0.015, respectively). No significant difference was noted in percentage of survivors and OS with respect to p300, VEGF, and MVD. No significant correlation was noted between p300 expression, VEGF expression, and MVD. Discussion: Our findings revealed significant association of bone marrow infiltration pattern and quantity of neoplastic cells with MVD and VEGF expression. Although no association of p300 was shown with histomorphologic prognostic parameters, MVD, VEGF expression, or OS, this is the first study investigating the potential prognostic role of p300 expression in PCM, to the best of our knowledge. In conclusion, more-comprehensive studies are needed to further elucidate the interaction between angiogenesis and myeloma cells as well as the prognostic role of increased bone marrow angiogenesis in PCM.