Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS


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Karabulut D., Ulusoy H. B. , Kaymak E. , Sonmez M. F.

ANATOLIAN JOURNAL OF CARDIOLOGY, vol.16, no.5, pp.310-315, 2016 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.5152/akd.2015.6252
  • Title of Journal : ANATOLIAN JOURNAL OF CARDIOLOGY
  • Page Numbers: pp.310-315
  • Keywords: diabetes mellitus, eNOS, iNOS, nNOS, heart, rat, NITRIC-OXIDE SYNTHASE, MITOCHONDRIAL OXIDATIVE STRESS, LEFT-VENTRICULAR FUNCTION, VITAMIN-C, ENOS EXPRESSION, TNF-ALPHA, MELATONIN, ATTENUATION, SUPPRESSION, APOPTOSIS

Abstract

Objective: Diabetes mellitus causes a decrease in cardiac output, arterial blood pressure, and heart rate. In this study, we aimed to investigate, at the molecular level, the effect of nitric oxide synthase (NOS) on heart pathology in type 1 diabetes and look at the therapeutic effect of pentoxifylline on this pathology.