Therapeutic effects of pentoxifylline on diabetic heart tissue via NOS

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Karabulut D., Ulusoy H. B., Kaymak E., Sonmez M. F.

ANATOLIAN JOURNAL OF CARDIOLOGY, cilt.16, sa.5, ss.310-315, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/akd.2015.6252
  • Dergi Adı: ANATOLIAN JOURNAL OF CARDIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.310-315
  • Anahtar Kelimeler: diabetes mellitus, eNOS, iNOS, nNOS, heart, rat, NITRIC-OXIDE SYNTHASE, MITOCHONDRIAL OXIDATIVE STRESS, LEFT-VENTRICULAR FUNCTION, VITAMIN-C, ENOS EXPRESSION, TNF-ALPHA, MELATONIN, ATTENUATION, SUPPRESSION, APOPTOSIS
  • Yozgat Bozok Üniversitesi Adresli: Hayır

Özet

Objective: Diabetes mellitus causes a decrease in cardiac output, arterial blood pressure, and heart rate. In this study, we aimed to investigate, at the molecular level, the effect of nitric oxide synthase (NOS) on heart pathology in type 1 diabetes and look at the therapeutic effect of pentoxifylline on this pathology.