Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates lipopolysaccharide-induced cellular injury in lung alveolar epithelial cells

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Vicil S., Erdogan S.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.45, sa.2, ss.284-290, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3906/sag-1401-108
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.284-290
  • Anahtar Kelimeler: Lung, epithelial cells, beraprost sodium, lipopolysaccharide, inflammation, oxidative stress, VASCULAR ENDOTHELIAL-CELLS, CYCLIC-AMP, OXIDATIVE STRESS, STABLE ANALOG, INFLAMMATION, MACROPHAGES, SIGNAL, EXPRESSION, RECEPTOR
  • Yozgat Bozok Üniversitesi Adresli: Hayır

Özet

Background/aim: Human alveolar epithelial cells play a critical role in the pathogenesis of lung diseases. The objective of this study is to determine the contribution of beraprost sodium, a prostaglandin I-2 (PGI(2)) analogue, to inflammatory and oxidative events in response to lipopolysaccharide (LPS) in airway epithelial cells.