Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates lipopolysaccharide-induced cellular injury in lung alveolar epithelial cells


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Vicil S. , Erdogan S.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.2, pp.284-290, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1401-108
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.284-290
  • Keywords: Lung, epithelial cells, beraprost sodium, lipopolysaccharide, inflammation, oxidative stress, VASCULAR ENDOTHELIAL-CELLS, CYCLIC-AMP, OXIDATIVE STRESS, STABLE ANALOG, INFLAMMATION, MACROPHAGES, SIGNAL, EXPRESSION, RECEPTOR

Abstract

Background/aim: Human alveolar epithelial cells play a critical role in the pathogenesis of lung diseases. The objective of this study is to determine the contribution of beraprost sodium, a prostaglandin I-2 (PGI(2)) analogue, to inflammatory and oxidative events in response to lipopolysaccharide (LPS) in airway epithelial cells.