Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries
Inorganica Chimica Acta, vol.581, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 581
- Publication Date: 2025
- Doi Number: 10.1016/j.ica.2025.122627
- Journal Name: Inorganica Chimica Acta
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
- Keywords: 2,acetylthiophene thiosemicarbazone,, Anticancer activity,, Antimicrobial activity,, Antimony(III),, Crystal structure
- Yozgat Bozok University Affiliated: No
Abstract
The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr₂(κ2-N3,S-Hatetsc)]} (1) and {[SbCl₂(η1-S-Hatmtsc)(κ2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.