Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries

Ucar O., Ozturk I. I., Grześkiewicz A. M., Kubicki M., Banti C., Hadjikakou S. K.

Inorganica Chimica Acta, cilt.581, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 581
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.ica.2025.122627
  • Dergi Adı: Inorganica Chimica Acta
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
  • Anahtar Kelimeler: 2,acetylthiophene thiosemicarbazone,, Anticancer activity,, Antimicrobial activity,, Antimony(III),, Crystal structure
  • Yozgat Bozok Üniversitesi Adresli: Hayır

Özet

The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr₂(κ2-N3,S-Hatetsc)]} (1) and {[SbCl₂(η1-S-Hatmtsc)(κ2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.