Synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes with uncommon geometries
Inorganica Chimica Acta, cilt.581, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 581
- Basım Tarihi: 2025
- Doi Numarası: 10.1016/j.ica.2025.122627
- Dergi Adı: Inorganica Chimica Acta
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex
- Anahtar Kelimeler: 2,acetylthiophene thiosemicarbazone,, Anticancer activity,, Antimicrobial activity,, Antimony(III),, Crystal structure
- Yozgat Bozok Üniversitesi Adresli: Hayır
Özet
The synthesis, structural characterization, and biological evaluation of novel antimony(III) thiosemicarbazone complexes containing thiophene-derived ligands are reported. Two complexes were synthesized: {[SbBr₂(κ2-N3,S-Hatetsc)]} (1) and {[SbCl₂(η1-S-Hatmtsc)(κ2-N3,S-Hatmtsc)]} (2). X-ray crystallography revealed complex 1 adopts a distorted seesaw structure, while complex 2 has a distorted square pyramidal structure. Both complexes showed significant antiproliferative activity against HeLa cancer cells. They also exhibited enhanced antibacterial activity against Gram-negative bacteria, particularly Escherichia coli. This study highlights the potential of thiophene-based antimony(III) complexes as promising candidates for anticancer and antibacterial therapies.