Akademik Veri Yönetim Sistemi
Turkish Journal of Gastroenterology, cilt.7, sa.1, ss.44-48, 1996 (Scopus)
The efficacy of omeprazole in reflux oesophagitis has been shown in many studies. The administration of omeprazole in postoperative reflux oesophagitis was not studied previously. We have investigated the effect of omeprazole therapy in 24 patients with postoperative reflux oesophagitis. Seventeen of these patients have not benefited from previous H2 receptor antagonist treatment. Fourteen of these patients were male, 10 female, and the age range was 21 to 63 years. The pathologies leading to reflux oesophagitis were achalasia in 6 cases (25%), hiatal hernia in 7 cases (29%), cardia cancer in 5 cases (21%), and duodenal ulcer in 6 cases (25%). Appearance of symptoms were in the 2nd-6th month postoperatively (mean follow-up: 4.8 months). The cases were diagnosed and followed up by endoscopy. Omeprazole was administered to all patients 20 mg/day. Complete endoscopic healing was 54% at 4 weeks, and 91.5% at the end of 8 weeks follow-up. Resolution of adverse effects occurred during therapy spontaneously. We believe omeprazole treatment can be an effective alternative in reflux oesophagitis therapy.