Survival of periviable infants: 5-year experience at a single center

Kulali F., BAŞ A. Y., EROL S., Yucel H., Guzel F. I., YALVAÇ E. S., ...More

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.33, no.22, pp.3725-3731, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 22
  • Publication Date: 2020
  • Doi Number: 10.1080/14767058.2019.1583734
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.3725-3731
  • Keywords: Extremely premature, infant, risk factors, survival rate, WEEKS GESTATION, UNITED-STATES, BORN, MORBIDITY, OUTCOMES
  • Yozgat Bozok University Affiliated: Yes


Objectives:The primary aim of the present study was to investigate the survival rates of periviable births in a referral Level III NICU center in Turkey; the secondary aim was to determine the perinatal and natal risk factors related to mortality. Methods:This retrospective cross-sectional study was conducted at the Neonatal Intensive Care Unit between 1 January 2011 and 31 December 2015. All live deliveries occurring from 22 0/7 weeks to 25 6/7 week of gestation were included in the study (totaln = 165). We documented prenatal, natal, and postnatal clinical processes in each case and assessed morbidity, mortality, and factors related to long-term prognosis. Results:While none of the infants born at 22 weeks of gestation survived until discharge, the survival rates for those admitted to the NICU were 7.5% for infants born at 23 weeks, 29.1% at 24 weeks, and 43.5% at 25 weeks. A total of 46 survived (27.9%), and follow-up data beyond 12 months were available for 22. The prevalence of neurodevelopmental impairment or neurosensory impairment was inversely associated with gestational age. Conclusions:The most important risk factors associated with mortality in periviable infants were SNAPPE score, antenatal corticosteroid use, and gestational age.