in current study, Computer Assisted Problem Based Learning (CAPBL) environment for human endocrine system was designed considering 3C3R model (Hung, 2006) in high school biology by one of researchers. The aim of the study was to introduce a Computer Assisted Problem Based Learning (CAPBL) environment designed to 3C3R model and examine its instructional relevance in temis of professionals' perceptions. For this purpose, CAPBT, Relevance Questionnaire developed based on literature review by one of researchers were implemented to 14 professionals (including four high school biology teachers, two computer and educational instruction teclmology teachers and eight faculty members studying computer and educational instruction technology and biology education). in the study, problem scenarios M CAPHL environment were sufficient from the point of content acquisition as well as instructional eligibility. Professionals suggested that some revisions were required in navigation buttons of CAPRI,. environment to enhance its usefulness. (C) 2012 Published by Elsevier Ltd.