Effect of 3’,4’-Dihydroxyflavonol on Striatum Antioxidant System in Focal Cerebral Ischemia-Reperfusion of Rat
Current Topics in Medicinal Chemistry, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.2174/0115680266437734260523221414
- Dergi Adı: Current Topics in Medicinal Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
- Anahtar Kelimeler: CAT, Focal brain ischaemia-reperfusion, GPx, rat, SOD, Striatum, Trx2
- Yozgat Bozok Üniversitesi Adresli: Evet
Özet
Introduction: The present study aimed to determine the effect of 1-week 3'-,4’-Dihydroxyflavonol (DiOHF) supplementation on the antioxidant system in the striatum tissue after brain ischemia-reperfusion in rats. In our current study, the relationship between DiOHF and the antioxidant systems GPx, SOD, CAT, and Trx2 was investigated for the first time in the striatum tissue of rats undergoing focal brain ischemia-reperfusion. Methods: A total of 28 Wistar-albino male rats were used, and the groups were as follows. Control: No anaesthesia or surgical procedure was performed on the animals in this group. Sham: After general anaesthesia was induced in the animals in this group, the carotid artery regions were opened and closed. After the application, the vehicle was supplemented for 1 week. Ischemia-Reperfusion (I/R): After the carotid arteries were isolated in the rats under general anaesthesia, they were ligated for 30 minutes, and ischemia was induced, followed by reperfusion. I/R + DiOHF Supplemented: DiOHF was supplemented after the I/R for 1 week. Results: Results of the study indicate that one week of I/R suppressed antioxidant markers such as GPx, SOD, CAT, and Trx2 in the striatum of rats. However, one week post-ischemic reperfusion treatment with DiOHF ameliorated these changes in the striatum. Discussion: The oxidant/antioxidant balance in the striatum tissue was disrupted with I/R. DiOHF supplementation, together with I/R, corrected the changes that occurred due to I/R. This study has certain limitations that should be taken into account. In future studies, significant progress can be made in determining the effectiveness of treatment in brain ischemia-reperfusion, which can cause significant health problems, by performing the analyses at different time intervals with different experimental models and different durations. Conclusion: DiOHF administration for one week after experimental cerebral ischemia-reperfusion in rats exerts beneficial effects on the antioxidant system in striatum tissue.