Recurrent implantation failure is associated with increased levels of fetuin-/alpha2-Heremans-Schmid-glycoprotein

Ozgu-Erdinc, A.; Oskovi-Kaplan, Z.; Engin-Ustun, Yaprak; Caglayan, Emel; Yilmaz, Saynur; Yilmaz, Nafiye; GÖÇMEN, AYŞE; Erkaya, Salim; Delibas, Namik

doi:10.1016/j.ejogrb.2020.03.005

Recurrent implantation failure is associated with increased levels of fetuin-/alpha2-Heremans-Schmid-glycoprotein

Ozgu-Erdinc A. S., Oskovi-Kaplan Z. A., Engin-Ustun Y., Caglayan E. K., Yilmaz S., Yilmaz N., ...Daha Fazla

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.248, ss.1-4, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 248
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.ejogrb.2020.03.005
Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.1-4
Yozgat Bozok Üniversitesi Adresli: Evet

Özet

Objective: Recurrent implantation failure is defined as the absence of implantation, after two or three consecutive cycles of in-vitro fertilization (IVF), intracytoplasmic sperm injection or frozen embryo replacement. Human fetuin-A/alpha2-Heremans-Schmid-glycoprotein is a plasma protein secreted by the liver that modulates insulin action in adipocytes. Increased fetuin-A promotes adipocyte dysfunction which results in decreased adiponectin and increased fatty acids and inflammatory cytokines. Fatty acids and inflammatory cytokines were previously reported in implantation failure. Also, fetuin-A inhibits receptor tyrosine kinase activity in trophoblast growth factors which decrease trophoblast viability and invasion. In this study, we aimed to find the association between fetuin-A and implantation failure.