Association of Cadmium but not Arsenic Levels in Lung Cancer Tumor Tissue with Smoking, Histopathological Type and Stage


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Demir N., Enon S., Turksoy V. A. , Kayaalti Z., Kaya S., Cangir A. K. , ...More

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.15, no.7, pp.2965-2970, 2014 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.7314/apjcp.2014.15.7.2965
  • Title of Journal : ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Page Numbers: pp.2965-2970
  • Keywords: Lung cancer, surgical tumor tissue, arsenic, cadmium, smoking stage, histopathological type, METAL CONCENTRATIONS, EXPOSURE, MORTALITY, WORKERS, WATER, RISK

Abstract

Background: To evaluate association of lung cancer with arsenic and cadmium levels measured in tumor tissue. Materials and Methods: Ninety-five patients with lung cancer tumor tissue obtained surgically were included in this study. Arsenic and cadmium levels were measured and levels of metals were compared among types of lung cancer and with reference to patient data. Results: The histopathologic diagnoses of the 95 cases were SCC, 49, adenocarcinoma, 28, large cell, 11 and SCLC, 1. Mean tumor arsenic and cadmium levels were 149.3+/-129.1 mu g/kg and 276.3+/-219.3 mu g/kg, respectively. Cadmium levels were significantly associated with smoking (p=0.02), histopathologic type (p=0.005), and TNM staging (r=0.325; p=0.001), although arsenic was not related to any parameter (p>0.05). There was no relation between metal levels and mortality (p>0.05). Conclusions: We found a significant association between tumor cadmium levels of patients with lung cancer and smoking, histopathologic type and staging, although there was no relation with arsenic levels.