Is ocular vascularity affected in young migraine patients? A pilot study


HAMAMCI M., Songur M. S. , BAYHAN S. A. , BAYHAN H. A.

JOURNAL OF CLINICAL NEUROSCIENCE, vol.91, pp.144-151, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 91
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jocn.2021.06.045
  • Title of Journal : JOURNAL OF CLINICAL NEUROSCIENCE
  • Page Numbers: pp.144-151
  • Keywords: Headache, Ischemia, Migraine with aura, Optical coherence tomography angiography, Comorbidity, NERVE-FIBER LAYER, OPTICAL COHERENCE TOMOGRAPHY, GANGLION-CELL LAYER, HEADACHE, THICKNESS, PATHOPHYSIOLOGY, STROKE, WOMEN, RISK

Abstract

Objective: This study aimed to evaluate ocular vascularity in young adult migraine patients with visual aura and without visual aura. Material and Methods: The study included 30 patients with migraine with visual aura (MWVA), 30 patients with migraine without visual aura (MWOVA), and 30 healthy control subjects, all between ages >18 and <45. Migraine patients were applied Headache Impact Test (HIT) and Migraine Disability Assessment Scale (MIDAS). Retinal nerve fiber layer thickness and ocular vascularity of all participants were evaluated with optical coherence tomography (OCT) and OCT angiography (OCTA). Results: The MWVA group had significantly lower superficial and deep foveal vascular density values compared to the control group (p = 0.039, p = 0.028, respectively). The foveal avascular zone was significantly enlarged in the MWVA group compared to the control group (p = 0.033). MWVA patients had significantly lower whole optic disc, optic disc inside, peripapillary, superior hemisphere, inferior hemisphere, superior quadrant, and temporal quadrant vascular density values compared to the control group (p < 0.05 all), while there was no significant difference in the nasal quadrant (p = 0.083). Migraine attack frequency, MIDAS, and HIT were negatively correlated with ocular vascular density values. Conclusion: The results of our study indicate that young adult patients with MWVA are at risk of decreased ocular vascularity and that this risk may increase with frequency and severity of migraine attacks. (c) 2021 Elsevier Ltd. All rights reserved.