The effects of occupational lead exposure on selected inflammatory biomarkers

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TÜRKSOY V. A., Tutkun L., Iritas S. B., Gunduzoz M., Deniz S.

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY, cilt.70, sa.1, ss.36-41, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2478/aiht-2019-70-3214
  • Dergi Adı: ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.36-41
  • Anahtar Kelimeler: atherosclerosis, cytokines, h-FABP, IL-6, IL-10, TNF-alpha, VCAM-1, IMMUNE-SYSTEM, BLOOD LEAD, H-FABP, CYTOKINES, DISEASE, VCAM-1, ATHEROSCLEROSIS, PATHOGENESIS, EXPRESSION, ADHESION
  • Yozgat Bozok Üniversitesi Adresli: Evet

Özet

In exposure to toxic metals such as lead, determining lead and cytokine levels (IL-6, IL-10, and TNF-alpha) is essential for early detection of diseases. The aim of this study was to develop an model for early detection of inflammation and onset of atherosclerosis in the absence of clinical findings in young workers, which could help physicians take timely an action and start treatment. This study included 49 metal workers exposed to lead occupationally and 50 unexposed administrative workers (controls) who underwent immunological analysis for cytokines (IL-6, IL-10, and TNF-alpha) and atherosclerosis markers (h-FABP and VCAM-1), toxicological analysis for lead, and routine biochemical analysis (ALT, AST, creatinine) at the Ankara Occupational and Environmental Diseases Hospital in 2017. Lead levels correlated with IL-6, 1L-10, and TNF-alpha (r.469, r=9.521 and r=0.279, respectively, p<0.01) but did not significantly affect h-FABP and VCAM-1 levels.